Table 2.
Data on patients with dupilumab-associated ocular surface disease.
| Age, gender | Past ocular history | Skin response | Symptoms | Signs on presentation | Onset of symptoms (weeks) | Treatment | Follow-up (months) | Response to drops | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | 24, F | None | EASI 75 | Bilateral painful eyes | Bilateral follicular conjunctivitis | 16 | FML and lubricants | 20 | FML OD |
| 2 | 57, F | HSV keratitis | EASI 75 | Bilateral itchy, red, watery eyes | MGD, papilla, conjunctival scarring left lower fornix | 1 | Prednisolone 0.5% | 24 | Developed leukoplakic lesion in lower fornix, steroid drops stopped after 12 months |
| 3. | 28, M | AKC | Improvement | Bilateral red, sore watery eyes | Bilateral limbal nodules, papillary conjunctivitis and lid erythema | 4 | Prednisolone 0.5%, Ikervis, Opatanol and lubricants | 26 | Prednisolone 0.5% OD |
| 4. | 43, F | AKC | EASI 75 | Episodes of redness | Redness, chemosis, papillary changes | 4 | Prednisolone 0.5%, lubricants | 16 | Prednisolone 0.5% OD |
| 5. | 54, F | None | EASI 75 | Bilateral sore, red, watery eyes | Bilateral follicular conjunctivitis, MGD, cicatricial changes in upper and lower fornix, cicatricial ectropion | 12 | Prednisolone 0.5%, Ikervis, Betnesol and Tacrolimus ointments to eye lids | 16 | Prednisolone 0.5% OD, Ikervis OD |
| 6. | 34, M | AKC | EASI 75 | Bilateral sore, red, watery eyes | Bilateral limbal nodules, severe papillary conjunctivitis | 8 | Betnesol ointment | 14 | Resolution, 8 months use of steroids |
| 7. | 26, F | None | EASI 50 prior to stopping | Bilateral red eyes, loss of lashes | Bilateral follicular conjunctivitis, loss of lashes, periorbital dermatitis | 2 | Dexamethasone preservative free, lubricants | Lost to follow-up | Lost to follow-up |
| 8. | 43, M | None | EASI 50 | Bilateral red sore eyes | Papillary changes, periocular redness, punctual stenosis | 1 | Prednisolone 0.5% and lubricants | 6 | Prednisolone 0.5% OD |
| 9. | 51, M | KC, AKC | EASI 50 | Bilateral redness | MGD, mild redness and papillary reaction | Unspecified | Dexamethasone preservative free, lubricants | 6 | Resolution after 3 months |
F female, M male, AKC atopic keratoconjunctivitis, HSV herpes simples virus, KC keratoconus, FML fluorometholone 0.1% drops, Ikervis ciclosporin 0.1% drops, EASI 50 50% improvement in Eczema Area and Severity Index score at 16 weeks, EASI 75 75% improvement in Eczema Area and Severity Index score at 16 weeks, OD once a day for drop frequency.