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. 2021 Nov 18;4:1306. doi: 10.1038/s42003-021-02837-0

Fig. 5. O304 mimics exercise in myocardial tissue by increased cell width and capillary density without increasing fibrosis.

Fig. 5

All data from 18-months-old mice fed CD or O304-0.5 from 12 months of age. a Gravimetric heart weight in mice fed CD (n = 8) and O304-0.5 (n = 9). b Representative images of myocardial sections from mice fed CD and O304-0.5 stained with Hematoxylin and Eosin, ERG antibody representing capillaries, Periodic Acid Schiff and Masson’s trichrome. c–f Quantification of cardiomyocyte width (c), in mice fed CD (n = 8) and O304-0.5 (n = 8), myocardial capillary density (d), in mice fed CD (n = 7) and O304-0.5 (n = 6), myocardial glycogen content (e), in mice fed CD (n = 9) and O304-0.5 (n = 7) and myocardial fibrotic score (f), in mice fed CD (n = 8) and O304-0.5 (n = 7). Data are presented as mean ± s.d. Student´s t-test between CD and O304-0.5 groups. **P ≤ 0.01, and ***P  ≤ 0.001.