Table 1.
Demographic characteristics and physical measurements
| Characteristic | Healthy subjects (n = 16) | Hepatically impaired subjects | |
|---|---|---|---|
| Mild (Child–Pugh A) (n = 8) | Moderate (Child–Pugh B) (n = 8) | ||
| Age, years | |||
| Mean (SD) | 48 (8) | 52 (7) | 50 (5) |
| [Min, Max] | [36, 60] | [44, 64] | [44, 59] |
| Sex, n (%) | |||
| Male | 9 (56) | 4 (50) | 5 (63) |
| Female | 7 (44) | 4 (50) | 3 (38) |
| Race, n (%) | |||
| White | |||
| American Indian/Alaskan | 15 (94) | 6 (75) | 6 (75) |
| Native | 1 (6) | 2 (25) | 2 (25) |
| Weight, kg | |||
| Mean (SD) | 77.6 (10.2) | 86.1 (16.3) | 83.8 (19.7) |
| [Range] | [60.0–100.4] | [56.9–101.8] | [58.0–120.5] |
| BMI, kg/m2 | |||
| Mean (SD) | 27.4 (3.3) | 29.0 (3.3) | 28.4 (4.5) |
| [Min, Max] | [24.0, 35.0] | [24.0, 35.0] | [22.0, 33.0] |
| Smoking status, n (%) | |||
| Current smoker | 8 (50) | 5 (63) | 5 (63) |
| Former smoker | 2 (13) | 2 (25) | 2 (25) |
| Non-smoker | 6 (38) | 1 (13) | 1 (13) |
| 24-h creatinine clearance, mL/min | |||
| Mean (SD) | 114.61 (23.93) | 122.00 (26.66) | 111.68 (33.88) |
| [Min, Max] | [73.17, 160.72] | [93.71, 169.80] | [56.67, 165.05] |
| Child–Pugh score | |||
| Median | NA | 5 | 7 |
| [Min, Max] | [5, 6] | [7, 8] | |
BMI body mass index, Max maximum, Min minimum, NA not applicable, SD standard deviation