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. 2021 Nov 5;11:764946. doi: 10.3389/fonc.2021.764946

Table 4.

Dose–volume histogram comparisons for the main OARs of three plans.

OARs IMRT VMAT HT p*
VMAT vs. IMRT HT vs. IMRT HT vs. VMAT
Brainstem
Dmax (Gy) 53.77 ± 1.33 53.16 ± 1.26 51.84 ± 1.95 0.006 <0.001 0.002
Spinal cord
Dmax (Gy) 43.99 ± 1.03 42.99 ± 1.15 41.34 ± 1.57 0.022 <0.001 <0.001
Optic nerve left
Dmax (Gy) 55.46 ± 2.98 54.46 ± 4.13 52.07 ± 3.14 0.040 <0.001 0.002
Optic nerve right
Dmax (Gy) 55.05 ± 2.39 55.11 ± 3.13 50.90 ± 3.24 0.881 <0.001 <0.001
Optic chiasm
Dmax (Gy) 42.52 ± 11.57 41.88 ± 11.82 42.67 ± 7.26 0.378 0.912 0.600
Lens left
Dmax (Gy) 7.43 ± 1.64 7.16 ± 1.94 5.47 ± 0.82 0.346 <0.001 0.001
Lens right
Dmax (Gy) 7.69 ± 1.28 7.46 ± 1.36 5.82 ± 0.62 0.502 <0.001 <0.001
Eye left
Dmax (Gy) 35.72 ± 4.70 33.06 ± 6.68 28.13 ± 5.25 0.011 <0.001 0.001
Eye right
Dmax (Gy) 35.92 ± 3.29 33.62 ± 5.62 26.62 ± 4.59 0.018 <0.001 <0.001
Pituitary
Dmax (Gy) 58.22 ± 4.97 58.54 ± 5.35 52.32 ± 6.78 0.375 <0.001 <0.001
Mandible
Dmax (Gy) 67.39 ± 3.87 67.76 ± 3.83 66.61 ± 4.20 0.249 0.234 0.095
TMJ left
Dmax (Gy) 61.07 ± 2.53 59.16 ± 3.54 57.85 ± 3.42 0.001 <0.001 0.004
TMJ right
Dmax (Gy) 60.23 ± 4.88 58.58 ± 5.17 57.10 ± 5.36 0.016 <0.001 0.027
Brachial plexus left
Dmax (Gy) 63.93 ± 2.19 64.32 ± 2.18 63.25 ± 3.79 0.132 0.363 0.177
Brachial plexus right
Dmax (Gy) 64.20 ± 2.63 64.79 ± 3.00 63.27 ± 4.10 0.074 0.171 0.022
Oral cavity
Dmean (Gy) 38.06 ± 1.48 38.44 ± 1.79 37.68 ± 1.57 0.404 0.356 0.229
Parotid gland left
Dmean (Gy) 33.81 ± 1.34 33.38 ± 1.87 33.64 ± 1.04 0.471 0.683 0.664
 V30 (%) 50.58 ± 2.52 49.96 ± 2.70 45.23 ± 1.73 0.537 <0.001 <0.001
Parotid gland right
Dmean (Gy) 34.71 ± 1.08 33.86 ± 1.72 33.87 ± 1.13 0.036 0.048 0.975
 V30 (%) 51.15 ± 1.68 50.44 ± 2.06 45.56 ± 2.14 0.359 <0.001 <0.001
Temporal lobe left
Dmax (Gy) 65.16 ± 3.94 64.79 ± 3.80 62.09 ± 3.73 0.071 <0.001 <0.001
 D1 (Gy) 59.38 ± 1.26 59.13 ± 1.84 58.23 ± 1.28 0.429 0.006 0.028
Temporal lobe right
Dmax (Gy) 63.90 ± 1.39 64.08 ± 1.69 60.46 ± 0.77 0.659 <0.001 <0.001
 D1 (Gy) 58.87 ± 0.85 59.35 ± 1.05 58.00 ± 1.00 0.080 0.001 <0.001
Larynx
Dmean (Gy) 43.22 ± 1.08 41.99 ± 2.07 39.56 ± 0.98 0.024 <0.001 0.001
Esophagus
Dmean (Gy) 30.41 ± 6.63 28.80 ± 6.58 28.18 ± 5.91 0.007 <0.001 0.371

*p value was computed by paired t test.