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. 2021 Nov 5;11:709170. doi: 10.3389/fonc.2021.709170

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Copyright © 2021 Zhou, Zhang, Chen, Sun and Qu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of neddylation pathway components and the prognostic significance in HCC. (A) mRNA levels of neddylation pathway components are higher in hepatocellular carcinoma tissues compared with normal liver tissues. The RNAseq data in TPM form and clinical information were obtained from TCGA (https://portal.gdc.cancer.gov/) LIHC data. (B) ROC curve analysis of neddylation pathway components. (C) High expression of neddylation pathway components is associated with worse prognosis. (D) Neddylation pathway components positively correlate with each other.