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. 2021 Nov 5;11:709170. doi: 10.3389/fonc.2021.709170

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Copyright © 2021 Zhou, Zhang, Chen, Sun and Qu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inactivation of neddylation pathway suppresses the transcription of STAT5A in HCC cells. (A) MLN4924 treatment significantly inhibited the proliferation of hepatocellular carcinoma cell line Huh7. (B) MLN4924 treatment decreases STAT5A mRNA and protein levels. Huh7 cells were treated with MLN4924 in a time-dependent manner as indicated. (C) Shown is a working model depicting the potential mechanism of neddylation pathway involved in the development of Th2 cells to favor tumor progression. ***P<0.001, for the indicated comparison.