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. 2021 Nov 5;9:740758. doi: 10.3389/fcell.2021.740758

FIGURE 4.

FIGURE 4

Inflammatory phenotype and LRRK2 levels in iPSC-derived microglia. (A) IL1B and IL10 gene expression (normalized to ACTB) in control and IPD microglia; a quantitative PCR showed higher gene expressions of IL1B and IL10 in IPD compared to control cells upon priming with LPS (100 ng/ml). Values are represented as fold changes of untreated cells. (B) NLRP3 mRNA and protein levels (normalized to ACTB and β-actin, respectively) are increased in IPD microglia compared to control cells upon priming with LPS (100 ng/ml). Values are represented as fold change of untreated cells. ∗p < 0.05; ∗∗p < 0.01; ****p < 0.0001; IPD, idiopathic PD, NLRP3, NOD-, LRR-, and pyrin domain-containing protein 3.