Table 1.

IC₅₀ values of new compounds on breast and prostate cancer cell proliferation

Compound	R	BT-474 (µM)	MDA-MB-231 (µM)	PC3 (µM)
SAHA		0.55 ± 0.01	0.55 ± 0.12	0.88 ± 0.09
15a	C6H5-	2.93 ± 0.54	1.85 ± 0.46	2.20 ± 0.49
15b	4-NO2C6H4-	2.49 ± 0.46	1.74 ± 0.37	2.03 ± 0.44
15c	3-NO2C6H4	2.06 ± 0.37	1.90 ± 0.28	1.93 ± 0.37
15d	4-FC6H4	-	2.07 ± 0.77	-
15e	4-BrC6H4	3.35 ± 0.47	2.52 ± 0.19	1.84 ± 1.22
15f	4-ClC6H4	2.46 ±0.47	1.89 ± 0.32	2.08 ± 1.29
15g	4-OCH3C6H4	2.90 ± 0.30	1.75 ± 0.82	2.29 ± 0.69
15h	3-ClC6H4	2.87 ± 0.44	2.76 ± 0.33	3.11 ± 0.78
15i	2,4-Cl2C6H3	-	-	-
15j	2-C5H3S	3.11 ± 1.44	1.39 ± 0.89	1.64 ± 0.06
15k	2-C5H3O	2.92 ± 1.46	1.78 ± 0.36	2.29 ± 0.33

Results are expressed as the mean ± S.D