Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Nov 18;12(12):1093. doi: 10.1038/s41419-021-04375-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — A and B A stronger inhibitory effect on tumor formation rate was exhibited in transplanted carcinoma in nude mice (n = 5 per group). C Tumor growth speed was significantly inhibited after DTYMK knockdown (p = 0.039). D Tumor sizes in the negative control group decreased partially after oxaliplatin treatment, while no tumors were formatted in the sh-DTYMK group (n = 5 per group). E Schematic diagram of tumor xenotransplantation model. F The results of immunohistochemistry showed that the expression of DTYMK and MAPKAPK2 reduced in the sh-DTYMK group compared with the negative control group. Moreover, higher CCL5 expression and more CD163⁺ TAMs were found in the negative control group. Scale bar = 50 μm. G Statistical analysis of the mice IHC results. H ELISA showed an inhibited level of CCL5 after DTYMK knockdown. I CCL5 could stimulate the chemotactic migration of monocytes. NC negative control, DTY DTYMK. ^*p < 0.05; ^**p < 0.01; ^***p < 0.001.