Table 1.

Univariate and multivariate Cox regression analyses.

Variable	Univariate analysis		Multivariate analysis
	HR (95% CI)	p value	HR (95% CI)	p value
Gender		0.977
Male	1.014 (0.399, 2.578)
Female	Reference
Age		0.249
<50	Reference
≥50	0.701 (0.382, 1.287)
HBsAg positive		0.645
Yes	1.305 (0.403, 4.222)
No	Reference
Size (major axis)		0.009		0.068
<5 cm	Reference		Reference
≥5 cm	2.432 (1.193, 4.955)		2.011 (0.950, 4.259)
Intact capsule		0.560
Yes	1.199 (0.654, 2.199)
No	Reference
AFP > 400		0.607
Yes	1.172 (0.642, 2.141)
No	Reference
DTYMK expression		0.004		0.019
High	2.470 (1.313, 4.647)		2.157 (1.137, 4.093)
Low	Reference		Reference
Liver cirrhosis		0.227
Yes	1.453 (0.788, 2.680)
No	Reference
Grade		0.135
1	Reference
2	1.200 (0.488, 2.950)
3	2.250 (0.861, 5.879)
TNM staging (AJCC 7th)		<0.001		0.072
I–II	Reference		Reference
III–IV	5.032 (2.715, 9.328)		2.322 (0.927, 5.814)
Tumor number (>1)		<0.001		0.092
Yes	4.241 (2.250, 7.994)		2.205 (0.880, 5.525)
No	Reference		Reference