FITC-Annexin V/PI assay in CT-26 cells. (a) Dot blot and (b) graph showing the apoptosis rate (both early and late apoptosis) of CT-26 colon cancer cell line cultured by TEX or TEX-miR-34a in different concentrations (10, 25 and 50 μg/ml) following 24 h. (c) Early and Late apoptosis in CT-26 cells (*P < 0.05, ** P < 0.01, *** P < 0.001, ****P < 0.0001). TEX: Tumor-derived exosome, TEX-miR: Tumor-derived exosome loaded by miR-34a