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. 2021 Nov 18;11:22500. doi: 10.1038/s41598-021-01988-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Epithelium thickness after 15 (pre-malignant stage) and 30 weeks (malignant stage) of treatment with normal saline, acetone, and NTCU. *Significant difference (P < 0.05) between groups in the same stage. **Significant difference between cancer groups from two different stages.