Table 2.
Univariable and multivariable logistic regression analysis of factors potentially associated with HDP in a subsequent pregnancy.
| Univariable analysis | Multivariable analysis | |||||
|---|---|---|---|---|---|---|
| OR | 95%CI | p Value | aOR | 95%CI | p Value | |
| Index pregnancy | ||||||
| Maternal age†, years old | 1.04 | (1.00–1.08) | 0.054 | 1.07 | (1.01–1.13) | 0.021* |
| Pre-pregnant BMI†, kg/m2 | 1.25 | (1.20–1.30) | < 0.001 | 1.25 | (1.17–1.33) | < 0.001* |
| Primiparity† | 1.14 | (0.70–1.84) | 0.596 | |||
| Gestational body weight gain†, kg | 1.04 | (1.00–1.09) | 0.077 | – | – | – |
| Overt DM† | 3.24 | (1.05–10.01) | 0.041 | – | – | – |
| ART† | 2.28 | (1.37–3.82) | 0.002 | – | – | – |
| HDP† | 14.72 | (9.94–21.79) | < 0.001 | 16.76 | (9.62–29.22) | < 0.001* |
| GDM† | 2.53 | (1.29–4.97) | 0.007 | – | – | – |
| Stillbirth ≥ 22 weeks of gestation† | 0.91 | (0.12–7.02) | 0.928 | |||
| GA at delivery†, weeks | 0.97 | (0.90–1.05) | 0.490 | |||
| Preterm birth (< 37 weeks of gestation)† | 1.69 | (0.95–2.99) | 0.072 | – | – | – |
| Cesarean section† | 1.45 | (0.98–2.14) | 0.067 | – | – | – |
| Neonatal sex†, male | 0.71 | (0.50–1.02) | 0.065 | – | – | – |
| Neonatal height†, cm | 0.98 | (0.93–1.03) | 0.428 | |||
| Birthweight†, g | 1.00 | (1.00–1.00) | 0.891 | |||
| Light for date infant† | 0.86 | (0.43–1.75) | 0.683 | |||
| Placental weight†, g | 1.00 | (1.00–1.00) | 0.390 | |||
| Inter-pregnancy | ||||||
| Pregnancy interval, years | 1.26 | (1.08–1.48) | 0.004 | 1.57 | (1.25–1.97) | < 0.001* |
| Anuual BMI change, kg/m2/year | 1.57 | (1.31–1.87) | < 0.001 | 2.30 | (1.76–3.01) | < 0.001* |
HDP, hypertensive disorders of pregnancy; OR, odds ratio; CI, confidence interval; BMI, body mass index; DM, diabetes mellitus; ART, assisted reproductive technology; GA, gestational age; PE, preeclampsia; GDM, gestational diabetes mellitus.
†Parameteres of the index pregnancy.
*Statistically significant.