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. 2021 Nov 18;12:6664. doi: 10.1038/s41467-021-26992-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Quantification of ileal Lcn2 by ELISA in control (n = 16), stress (n = 16), and LPS treated (n = 8) mice. Significance was determined by a one-way ANOVA, not corrected for multiple comparisons, control:stress, p = 0.0141, control:LPS, p = 0.0466. b Ileal AIEC tissue burdens from control (n = 16), stress (n = 18), and LPS treated (n = 10) mice control:stress, p < 0.0001, control:LPS, p = 0.0079. c Representative flow plots of CD45⁺CD90^+/− cells and lineage staining on CD45⁺CD90⁺. Percentage of CD90⁺ T cells and CD90⁺ lineage⁻ ILCs of total CD45⁺ cells isolated from ileal lamina propria cells collected from starved (n = 10) and stressed (n = 10) mice as determined by flow cytometry. Significance was determined by two-way ANOVA, not corrected for multiple comparisons, p < 0.0001, p < 0.0001. d Quantification of corticosterone in the serum as determined by ELISA in control (n = 4), stress (n = 6), and RU486 treated stress (n = 6) mice. Significance was determined by one-way ANOVA, not corrected for multiple comparisons, control:stress, p = 0.0087; control:stress + RU486, p = 0.0011. e Representative flow plot of percentage of CD45⁺CD90⁺GR⁺ cells. f Frequency of CD45⁺CD90⁺ cells following 8 h of restraint stress in control (n = 8), stress (n = 12), and RU486 treated stress (n = 11) mice. g Frequency of CD45⁺CD90⁺AnnexinV⁺ cells following 8 h of restraint in control (n = 8), stress (n = 12), and RU486 treated stress (n = 11). Significance was determined by a one-way ANOVA, not corrected for multiple comparisons, control:stress, p = 0.0323, stress:stress + ru486 p = 0.0018. h Frequency of CD45⁺CD90⁺ cells following overnight restraint in control (n = 18), stress (n = 8), and RU486 treated stress (n = 11). Significance was determined by one-way ANOVA, not corrected for multiple comparisons, control:stress, p = 0.0079, stress:stress + ru486 p = 0.0043. i Absolute number of CD45⁺CD90⁺ cells following overnight restraint in control (n = 18), stress (n = 8), and RU486 treated stress (n = 11) mice. Significance was determined by two-way ANOVA, not corrected for multiple comparisons, control:stress, p = 0.0005, stress:stress + ru486 p = 0.0060. (*p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001; ****p ≤ 0.0001). Error bars represent SEM and the line in CFU graphs indicates the geometric mean of the group.