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. 2021 Nov 18;12:6658. doi: 10.1038/s41467-021-26934-0

Fig. 2. H107 does not induce cross-reactive immunity to BCG.

Fig. 2

a CB6F1 mice were immunized with H4/CAF®01, H107/CAF®01, H65/CAF®01, or MOMP/CAF®01 and inoculated intradermally (i.d.) with BCG and CFUs were determined in the spleens of vaccinated animals 3.5 weeks later (n = 8, H4 vs. H107 p = 0.0034; H65 vs. H107 p = 0.0298). b CB6F1 mice were immunized with H65/CAF®01 or H107/CAF®01 and inoculated with BCG subcutaneously (s.c.) at the tail-base. BCG CFUs were determined in the inguinal lymph nodes 6 weeks after inoculation (n = 8, two-sided unpaired t test, *p = 0.0257). c, d CB6F1 mice were immunized with saline (white), H65/CAF®01 (red), H107/CAF®01 (blue), or MOMP/CAF®01 (gray) and injected intravenously (i.v.) with BCG-Danish (c) or BCG-Japan (d) 6 weeks after the last immunization. BCG CFUs were enumerated in lungs 3.5 and 9 weeks post-BCG challenge (n = 8) and p-values shown for Saline vs. H65. All data shown as mean ± SEM. (a, c, d) One-way ANOVA with Tukey’s Multiple Comparison test. p values; p values; *p < 0.05, **p < 0.01, ****p < 0.0001, and ns (nonsignificant).