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. 2021 Nov 5;12:771691. doi: 10.3389/fphys.2021.771691

TABLE 1.

Top 30 transcription factors (see the full transcription factor list in Supplementary Table 1).

Gene symbol Gene name TF family Mean (TPM) S.E.M. Rank
Ybx1 Y box protein 1 CSD 696.7 8.1 211
Atf4 Activating transcription factor 4 TF_bZIP 489.0 18.8 269
Id2 Inhibitor of DNA binding 2 bHLH 374.5 17.0 328
Hmgb1 High mobility group box 1 HMG 339.6 19.4 354
Hmga1 High mobility group AT-hook 1 HMGI/HMGY 331.4 3.9 362
Ddit3 DNA-damage inducible transcript 3 TF_bZIP 326.8 7.5 365
Glmp Glycosylated lysosomal membrane protein NCU-G1 296.5 13.1 397
Csde1 Cold shock domain containing E1, RNA binding CSD 291.0 8.5 406
Sub1 SUB1 homolog (S. cerevisiae) PC4 261.5 8.5 458
Ybx3 Y box protein 3 CSD 252.0 2.6 477
Tsc22d1 TSC22 domain family, member 1 TSC22 202.8 6.2 592
Ssrp1 Structure specific recognition protein 1 HMG 191.3 5.6 628
Jund Jun D proto-oncogene TF_bZIP 190.8 6.7 631
Zbtb18 Zinc finger and BTB domain containing 18 ZBTB 181.0 12.0 666
Cers2 Ceramide synthase 2 Homeobox 169.6 6.8 718
Hmgb2 High mobility group box 2 HMG 159.0 6.4 763
Litaf LPS-induced TN factor zf-LITAF-like 147.0 4.9 822
Gatad1 GATA zinc finger domain containing 1 zf-GATA 139.2 2.3 877
Smarce1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 HMG 136.5 5.3 898
Junb Jun B proto-oncogene TF_bZIP 130.5 6.1 950
Cux1 Cut-like homeobox 1 CUT 126.4 2.8 979
Bhlhe40 Basic helix-loop-helix family, member e40 bHLH 124.3 5.4 1,000
Tfdp1 Transcription factor Dp 1 E2F 109.1 3.2 1,131
Pax8 Paired box 8 PAX 107.5 3.0 1,152
Gtf3a General transcription factor III A zf-C2H2 103.7 1.7 1,198
Zfp91 Zinc finger protein 91 zf-C2H2 101.8 2.9 1,222
Hmg20b High mobility group 20B HMG 97.2 3.4 1,284
Mbd3 Methyl-CpG binding domain protein 3 MBD 96.2 3.5 1,297
Trp53 Transformation related protein 53 P53 96.0 3.1 1,303
Irf7 Interferon regulatory factor 7 IRF 91.1 2.5 1,379
Atf5 Activating transcription factor 5 TF_bZIP 83.0 3.8 1,543
Mbd2 Methyl-CpG binding domain protein 2 MBD 81.4 3.3 1,573
Ncor1 Nuclear receptor co-repressor 1 MYB 80.9 4.2 1,582