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. 2021 Nov 5;12:735075. doi: 10.3389/fphar.2021.735075

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Copyright © 2021 Li, Ye, Zhou, Shi, Wang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Mechanical allodynia presented by paw withdrawal threshold (PWT). (B) Thermal hyperalgesia presented by paw withdrawal latency (PWL). The mechanical allodynia and thermal hyperalgesia were significant decreased after CFA injection. After BoNT/A application, PWT significantly increased at doses of 3 U at 5 days, and PWL also displayed similar results (***p < 0.001 represents comparison of CFA with the sham group, ###p < 0.001 represents comparison of 3 U CFA+BoNT/A with the CFA group).