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. 2021 Nov 5;8:764337. doi: 10.3389/fcvm.2021.764337

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Copyright © 2021 Pilecki, de Carvalho, Kirketerp-Møller, Schlosser, Kejling, Dubik, Madsen, Stubbe, Hansen, Andersen, Moeller, Marcussen, Azevedo, Hvidsten, Baun, Shi, Lindholt and Sorensen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MFAP4 expression in normal aorta and AAA tissue. (A,B) Quantitative real-time PCR analysis of (A) Mfap4 and (B) Col1a1 mRNA transcripts in C57BL/6N mouse tissues (n = 7). Expression levels are normalized against eukaryotic 18S rRNA and presented as means + SEM. (C,D) Representative images of (C) MFAP4 immunohistochemical staining (IHC) and (D) Mfap4 in situ hybridization staining (ISH) in abdominal aortic sections in saline-infused and Ang II-infused ApoE^−/− (Mfap4^+/+) mice. Black arrows indicate examples of positive cells. n = 5–13. Scale bar = 50 μm. (E) Semi-quantitation of MFAP4 IHC staining intensity in the aortas of saline- and Ang II-infused ApoE^−/− mice. (F) MFAP4 concentration in serum from saline- and Ang II-infused ApoE^−/− mice. Data are analyzed with Mann-Whitney U-test.