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. 2021 Nov 5;8:764337. doi: 10.3389/fcvm.2021.764337

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Copyright © 2021 Pilecki, de Carvalho, Kirketerp-Møller, Schlosser, Kejling, Dubik, Madsen, Stubbe, Hansen, Andersen, Moeller, Marcussen, Azevedo, Hvidsten, Baun, Shi, Lindholt and Sorensen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MFAP4 induces monocyte migration and MMP-9 activity in macrophage-like cells in vitro. (A) MFAP4 acts as a haptoattractant for human blood monocytes. (B) MFAP4-dependent monocyte directional migration can be inhibited by anti-integrin α_Vβ₃ antibody. (C) MFAP4 stimulation potentiates TNF-induced MMP-9 activity in differentiated THP-1 macrophage-like cells. n = 4–6 independent experiments. *p < 0.05, **p < 0.01, analyzed with paired t-test and repeated measures ANOVA followed by Bonferroni's test.