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. 2021 Nov 18;11:22494. doi: 10.1038/s41598-021-01975-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Percentages of cellular mitochondrial metabolism, DNA synthesis and plasma membrane integrity after 72 h of CBD exposure. Percentages of cellular mitochondrial metabolism (a), DNA synthesis (b) and plasma membrane integrity (c) after 72 h of exposure of the A549, Caco-2, HepG2, MDA-MB-231, and TelCOFS02MA cell lines to different concentrations of CBD. The results are expressed as the means ± standard deviation on the basis of five independent experiments. Significant differences compared to negative controls are highlighted by asterisks (ANOVA, Dunnett’s test—*p < 0.05; **p < 0.001; ***p < 0.0001). Percentages of inhibition of cellular mitochondrial metabolism (a₁), DNA synthesis (b₁), and inhibition of plasma membrane integrity (c₁) after 72 h of exposure are reported in concentration [µM]-effect curves. NC: negative control.