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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Transpl Int. 2021 Nov;34(11):2031–2045. doi: 10.1111/tri.14128

Figure 1. Types of human liver organoids.

Figure 1.

Epithelial organoids are derived from either adult stem/ progenitor cells or PSCs and differentiate into a single type of cell; these organoids only have basic functions of hepatocytes. Multi-tissue organoids are derived from either PSCs or combined with stromal cells to generate at least two germ layers; these organoids are capable of complicated functions of the liver and can vascularize to survive longer. Multi-organ organoids are the most complex and encompass multiple interconnected organ like structures that function separately; these organoids have been derived from PSCs only.