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. 2021 Nov 5;11:761643. doi: 10.3389/fonc.2021.761643

Figure 4.

Figure 4

Identification of VAV1, an ILBRS-relevant predictor and therapy target for PFS of PCa patients. (A) Forest plot of the results of univariate Cox regression analyses of the core enrichment genes of the immune-relevant KEGG pathways. The square data markers indicate estimated hazard ratios (HR). The error bars represented 95% CIs. “cor” indicates the coefficient gained through Pearson correlation analysis. (B) The core enrichment genes are associated with PFS of PCa patients in immune-relevant KEGG pathways. (C) Different expressions of VAV1, PIK3CD, and PIK3R5 between PCa patients with high and low ILBRS, Tregs infiltration, and immune score, and between PCa patients with and without PFS event. (D) Pearson correlation analyses of VAV1 with Tregs infiltration, ILBRS, immune score, and the immune-relevant KEGG pathways. (E) Heat map of the immune-relevant KEGG pathways. (F) Kaplan–Meier curves for the PCa tissues from patients with high and low expression of VAV1 in TCGA-PRAD data. *p < 0.05; **p < 0.01; ***p < 0.0001.