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. 2021 Nov 5;11:755341. doi: 10.3389/fonc.2021.755341

Figure 1.

Figure 1

IGF-1/IGF-1R expression levels in different types of human cancers. The expression levels of IGF-1 between tumor and normal tissues were compared in 20 cancer types based on the TCGA database (A) and 27 cancer types based on the integrated database from TCGA and GTEx datasets (B). The expression levels of IGF-1R between tumor and normal tissues were compared in 20 cancer types based on the TCGA database (C) and 27 cancer types based on the integrated database from TCGA and GTEx datasets (D). Consistent high expression level of IGF-1 could be seen in normal tissues than most types of tumor based on both comparisons, and significant decreased expression of IGF-1 could be seen in tumor samples including ACC, BLCA, BRCA, CESC, CHOL, COAD, ESCA, LAML, LGG, LIHC, LUAD, OV, PRAD, READ, SKCM, STAD, TGCT, THCA, UCEC, and UCS based on the integrated database. Consistent high expression level of IGF-1R could be seen in most types of tumor than normal tissue based on the both comparisons, and significant increased expression of IGF-1R could be seen in tumor samples including BRCA, CHOL, COAD, ESCA, GBM, HNSC, LAML, LGG, LIHC, LUAD, LUSC, PAAD, PRAD, SKCM, STAD, TGCT, and THCA based on the integrated database. “*, **, ***” means p < 0.05, p < 0.01 and p < 0.001, respectively.