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. 2021 Nov 5;12:768966. doi: 10.3389/fimmu.2021.768966

Figure 3.

Figure 3

IRG scores of PBMC cell clusters in AD. (A) Score of 212 screened IRGs. The threshold was chosen as 0.26. (B) t-SNE plots of IRG score in all clusters. NK and DC cells express more genes and exhibit higher AUC values. (C) GO analysis of DEGs in NK cluster. The top 10 GOs include neutrophil mediated immunity (GO:0002446), neutrophil degranulation (GO:0043312), neutrophil activation involved in immune response (GO:0002283), antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590), antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:0002479), cytokine-mediated signaling pathway (GO:0019221), aerobic electron transport chain (GO:0019646), mitochondrial ATP synthesis coupled electron transport (GO:0042775), Fc-gamma receptor signaling pathway (Go:0038094), and cellular protein modification process (GO:0006464). (D) KEGG of DEGs in NK cluster. The top 10 KEGGs include Parkinson disease, Prion disease, Amyotrophic lateral sclerosis, Pathways of neurodegeneration, Huntington disease, Pathogenic Escherichia infection, Shigellosis, Salmonella infection, Proteasome, and Alzheimer’s disease.