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. 2021 Nov 5;12:768966. doi: 10.3389/fimmu.2021.768966

Figure 4.

Figure 4

DEGs of AD brain from GSE33000 dataset. (A) Volcano plot of DEGs (|logFC| > 0.03 and adjusted P value < 0.05). Up-regulated genes were colored in red and down-regulated genes were colored in blue. (B) Heatmap of top 100 up and top 100 down DEGs of GSE33000. (C) GO of DEGs in GSE33000. The top 10 GOs include neutrophil activation involved in immune response (GO:0002283), neutrophil degranulation (GO:0043312), neutrophil mediated immunity (GO:0002446), regulation of mRNA catabolic process (GO:0061013), regulation of cellular ketone metabolic process (GO:0010565), aerobic electron transport chain (GO:0019646), cellular protein modification process (GO:0006464), regulation of potassium ion transmembrane transport (GO:1901379), mitochondrial ATP synthesis coupled electron transport (GO:0042775), and negative regulation of extrinsic apoptotic signaling pathway (GO:2001237). (D) KEGG of DEGs in GSE33000. The top 10 KEGGs include Pathways in cancer, Focal adhesion, Non-alcoholic fatty liver disease, MAPK signaling pathway, Human T-cell leukemia virus 1 infection, Dopaminergic synapse, Kaposi sarcoma-associated herpesvirus infection, Glutamatergic synapse, Retrograde endocannabinoid signaling, and PI3K-Akt signaling pathway.