TABLE 2.
Summary of median (IQR) concentration parameters observed at the first (T1) and second (T2) PK visit.
| MEDIAN (IQR) T-1 | MEDIAN (IQR) T-2 | % Change | p value | |
|---|---|---|---|---|
| WB TAC conc. (ng/ml) | 2.8 (1.8–3.3) | 2.9 (1.7–3.8) | −2.9 (−29.4–+42.1) | 0.870 |
| Intra-PBMC TAC conc. (ng/ml) | 17.5 (10.6–27.7) | 16.0 (9.8–32.7) | −0.1 (−22.4–+46.9) | 0.710 |
| Intra-PBMC/WB ratio | 7.0 (5.0–10.0) | 6.3 (4.9–8.5) | −0.4(−28.1–+44.5) | 0.987 |
| Norm. WB TAC C/D/kg (ng/mg/kg) | 48.1 (35.7–67.9) | 49.4 (35.4–87.4) | −0.5 (−31.0–+47.0) | 0.912 |
| Norm. Intra-PBMC TAC C/D/kg (ng/mg/kg) | 372.6 (182.0–480.4) | 354.2 (236.5–523.8) | 1.9 (−22.3–+42.1) | 0.876 |
| Weight-adjusted TAC Dose (mg/kg/day) | 0.05 (0.03–0.09) | 0.05 (0.03–0.08) | −2.0 (−8.0–+1.0) | 0.998 |