TABLE 1.
Stage | No. of embryos (%)
|
Phenotype | |||
---|---|---|---|---|---|
Nup50+/+ | Nup50+/− | Nup50−/− | Resorbed | ||
E8.5 to E9.5 | 5 | 25 | 8 | 0 | Wavy neural tube |
E10.5 | 12 | 21 | 11b | 6 | Kinked neural tube, open cranial neural tube, growth retardation |
E12.5 to E16.5 | 17 | 36 | 13 | 15 | Exencephaly, growth retardation, complex CNS abnormalities |
E18.5 | 0 | 3 | 1 | 0 | Exencephaly, complex facial abnormalities, growth retardation |
Total | 34 (22) | 85 (56) | 33 (22) |
The table summarizes data from embryos from 19 individual litters, ranging in age from E8.5 to E18.5. Nup50+/− females were sacrificed after timed matings with Nup50+/− males. Resorbed embryos were not genotyped.
In one E10.5 litter, 2 embryos with normal phenotypes were genotyped as Nup50−/−.