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. 2016 Jan 9;2016(1):CD006014. doi: 10.1002/14651858.CD006014.pub7

Comparison 1. IDS vs chemotherapy only.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Overall survival 3 781 Hazard Ratio (Random, 95% CI) 0.80 [0.61, 1.06]
1.1 General Surgeons or less extensive primary surgery 2 357 Hazard Ratio (Random, 95% CI) 0.68 [0.53, 0.87]
1.2 Gynaecologic oncologists 1 424 Hazard Ratio (Random, 95% CI) 0.99 [0.79, 1.24]
2 Progression‐free survival 2 702 Hazard Ratio (Random, 95% CI) 0.88 [0.57, 1.33]
3 Toxic reactions to chemotherapy 2 357 Risk Ratio (M‐H, Fixed, 95% CI) 1.19 [0.53, 2.66]
4 Peripheral neuropathy of grade 2 or higher 1   Risk Ratio (IV, Random, 95% CI) Subtotals only
5 Grade 3 or 4 gastrointestinal adverse events 1   Risk Ratio (IV, Random, 95% CI) Subtotals only
6 Grade 4 pulmonary adverse events 1   Risk Ratio (IV, Random, 95% CI) Subtotals only
7 Grade 4 cardiovascular adverse events 1   Risk Ratio (IV, Random, 95% CI) Subtotals only