Date	Event	Description
5 March 2013	New search has been performed	Two RCTs were identified and subsequently excluded.
5 March 2013	New citation required but conclusions have not changed	The search was updated to June 2012.
19 August 2010	Amended	Searches re‐run in July 2009. Seventeen possible relevant articles were identified. Only two RCTs were found; one RCT of a Japanese study and the EORTC 55971 trial. However, the Japanese study referred to a study that was excluded in our primary review and EORTC 55971 trial allowed IDS in both arms at discretion of physician.
10 February 2009	Feedback has been incorporated	Feedback regarding new trial incorporated.
10 November 2008	New citation required but conclusions have not changed	Errors in reporting HR and RR corrected. Explanation regarding surgical expertise included.