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. 2021 Nov 5;11:755212. doi: 10.3389/fonc.2021.755212

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Copyright © 2021 Jiang, Meng, Bao, Wang, Gong, Gan, Wang, Bao, Wu, Lu, Liu and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mutation and CNV differences between subgroups. (A, B) Waterfall plot represents the mutation distribution of the most frequently mutated genes. (C) Forest plots display the top 6 most significantly differentially mutated genes between the two subgroups. (D) Boxplot of TMB between the two subgroups. (E) Barplot of fraction genome altered in the two identified subtypes. (F) Composite copy number profiles for ccRCC with gains in red and losses in blue and gray highlighting differences.