TABLE 2.

Defect in hematopoietic colony formation by fetal liver cells from Fli1 mutant mice

Embryo no.	Genotype	No. of cells/fetusa
		Cells/fetus	CFU-E	BFU-E	CFU-GM	CFU-mix
Expt 1
1	+/+	1.65 × 105	24,684 ± 3,497	116 ± 50	297 ± 99	1,023 ± 148
2	+/+	2.18 × 105	19,206 ± 4,404	262 ± 44	741 ± 31	1,657 ± 109
3	+/+	1.31 × 105	11,842 ± 1,454	109 ± 66	249 ± 13	550 ± 92
4	+/−	0.53 × 105	5,183 ± 673	53 ± 11	74 ± 27	127 ± 32
5	+/−	4.90 × 105	27,293 ± 5,782	196 ± 98	1,078 ± 98	1,274 ± 245
6	+/−	1.83 × 105	14,183 ± 2,159	256 ± 146	329 ± 146	714 ± 128
7	−/−	0.57 × 105	439 ± 68	11 ± 6	6 ± 6	6 ± 6
8	−/−	0.86 × 105	301 ± 77	17 ± 9	34 ± 17	26 ± 9
Expt 2
1	+/+	5.79 × 105	66,353 ± 1,505	696 ± 232	3,358 ± 519	3,127 ± 579
2	+/+	7.38 × 105	76,604 ± 2,804	738 ± 295	5,461 ± 1,181	4,280 ± 590
3	+/−	4.11 × 105	29,674 ± 5,918	1,151 ± 164	1,480 ± 411	1,480 ± 164
4	+/−	4.49 × 105	41,488 ± 8,890	2,065 ± 493	1,257 ± 329	1,527 ± 247
5	+/−	3.48 × 105	33,478 ± 2,436	1,253 ± 278	1,044 ± 139	1,078 ± 209
6	+/−	3.46 × 105	27,611 ± 3,944	830 ± 208	1,661 ± 277	1,799 ± 415
7	+/−	3.43 × 105	31,213 ± 7,683	823 ± 137	755 ± 69	549 ± 69
8	+/−	4.53 × 105	44,756 ± 181	2,265 ± 362	2,084 ± 544	1,631 ± 272
9	−/−	1.72 × 105	5,917 ± 656	310 ± 104	34 ± 34	69 ± 34

^aMean ± standard deviation of quadruplicate cultures of day 11 fetal liver cells. Cultures contained SF, IL-3 and Epo. Experiment 1 had 10,000 fetal liver cells/dish. Experiment 2 had 5,000 cells per dish. CFU-E cells were counted on day 2, and other colonies were counted on day 7.