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. 2021 May 10;9(11):e003134. doi: 10.1136/jitc-2021-003134

Figure 1.

Figure 1

MEL04 involving inflamed tumor microenvironment and extremely high TMB. (A) TMB and representative driver gene alterations in four melanoma cell lines. Whole-exome sequencing was performed for each cell line. The number of non-synonymous mutations and representative driver gene alterations of melanoma are shown. (B) PCA in four melanoma cell lines. We conducted a PCA based on variable gene expression (top 10,000 SD) from the RNA-sequencing data. (C) Immune-related gene signatures from gene set enrichment analysis in MEL02, 03, and 04 compared with MEL01. Interferon-α, interferon-γ, and inflammatory response related gene signatures from the MSigDB database are shown. PCA, principal component analysis; TMB, tumor mutation burden.