TABLE 1.
Infectivity of HSV-1 and HSV-2 strains pretreated with different concentrations of SLS and DS for 1 h at 37°C
| Compound and concn | PFU (% of control) for:
|
||||
|---|---|---|---|---|---|
| HSV-1 (F)a | HSV-2 (333)a | HSV-2 (22)a | HSV-2 (6)b | HSV-2 (15589)c | |
| SLS (μM) | |||||
| 6.25 | 101.1 ± 7.0d | 102.9 ± 23.5 | 128.0 ± 18.5 | 105.3 ± 12.4 | 108.7 ± 22.2 |
| 12.5 | 79.2 ± 36.4 | 115.4 ± 17.0 | 103.4 ± 14.9 | 82.1 ± 40.7 | 115.1 ± 17.5 |
| 25 | 21.2 ± 18.0 | 72.9 ± 9.1 | 63.8 ± 11.9 | 51.1 ± 30.1 | 59.0 ± 24.0 |
| 50 | 0 | 0 | 0 | 0 | 0 |
| DS (nM) | |||||
| 0.1 | 88.4 ± 23.7 | 69.2 ± 1.4 | |||
| 0.25 | 72.6 ± 30.2 | 63.1 ± 6.2 | |||
| 0.5 | 58.8 ± 21.2 | 55.2 ± 3.1 | |||
| 1 | 49.3 ± 22.7 | 43.5 ± 3.1 | |||
| 10 | 15.6 ± 9.1 | 3.2 ± 1.5 | |||
| 50 | 0 | 0 | |||
a
Wild-type strain.
b
Acyclovir-resistant strain.
c
Foscarnet-resistant strain.
d
Results are the mean (± the SD) of four independent experiments.