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. Author manuscript; available in PMC: 2021 Nov 19.
Published in final edited form as: Nat Rev Mol Cell Biol. 2015 Nov 25;17(1):16–29. doi: 10.1038/nrm.2015.5

Figure 4. Centromeric chromatin.

Figure 4.

Model of the epigenetic modifications at the core centromere, CENP-A domain, and the pericentromere. In addition to the sequence and structural specializations that differentiate CENP-A chromatin from bulk chromatin, posttranslational modifications of CENP-A nucleosomes contribute to centromere function. Human CENP-A is mono-ubiquitinated at lysine 124 within the histone fold domain by CUL4-RBX1-COPS8216 to promote its centromere targeting. Acetylation at this lysine 124 residue has also been reported217. Finally, diverse other posttranslational of CENP-A217–219 and H4 in the CENP-A nucleosome220 have been described. Defining the functional contributions of these modifications remains a central challenge.