Figure 6.

Schematic representation of α-synuclein distribution at the vesicle surface. On the left, the α-helices (represented by —) are uniformly distributed on the membrane plane. On the right, the other extreme case is shown where the protein molecules are aligned still flat on the surface but more parallel with the elongation direction (tube orientation). The proposed model to explain the high LD^r/S values includes a fraction of the protein helices deviating from a flat uniform in-plane distribution and instead exhibiting in-plane bias of helix orientation parallel with the long-axis of the ellipsoid (drawing in the middle with derived fractions for the different lipid systems). f = fraction of helices with uniform in-plane distribution; 1 – f = fraction with biased orientation parallel with the flow (least curved direction on the ellipsoid).