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. 2021 Nov 8;143(45):18899–18906. doi: 10.1021/jacs.1c05344

Table 1. Order Parameter S of DOPS, POPS, and DOPG Vesicles before and Immediately after Addition of α-Synuclein (t0 Corresponds to the First Measurement, When the Flow Starts) and Angles of the Protein π–π* Transition at 208 nm (Helix Long Axis) Relative to the Membrane Normal for the Conditions That Could Be Fitted by Eq 2 (Ellipsoid Model); Angles Obtained Immediately after Adding the Protein (t0) and after 30 min under Flow (t30 min) Are Shown.

  DOPS
POPS
DOPG
S factor L:P 100 L:P 200 L:P 100 L:P 200 L:P 100 L:P 200
vesicles only, t0 0.081 0.074 0.069 0.074 0.019 0.014
α-synuclein addition, t0 0.072 0.069 0.055 0.063 0.030 0.026
angle γ (deg) at 208 nm            
α-synuclein addition, t0   90   78    
α-synuclein addition, t30 min 84 65 90° 66 80 80