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T1-weighted images (thigh muscles) of patients with COL6-RD in comparison to unaffected (control) individuals (first axial slice), indicating the pattern of fibro-fatty material with increased disease severity (B–E). There is a characteristic inward progression of fibro-fatty material from fascia to deep inside the vastus lateralis muscle. Also, there is a characteristic central shadow (target)-like appearance in the rectus femoris (RF) muscle (white arrow).
