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. 2021 Nov 5;12:753890. doi: 10.3389/fimmu.2021.753890

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Copyright © 2021 Guolo, Minetto, Pesce, Ballerini, Clavio, Cea, Frello, Garibotto, Greppi, Bozzo, Miglino, Passannante, Marcolin, Tedone, Colombo, Mangerini, Bo, Ruzzenenti, Carlier, Serio, Luchetti, Dominietto, Varaldo, Candiani, Agostini, Ravetti, Del Zotto, Marcenaro and Lemoli

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Analysis of the size and distribution of CD56brightCD16neg/dim, CD56dimCD16bright, and CD56negCD16bright NK cell subsets derived from peripheral blood of 4 treated (Pt Nivo) and 3 control (Pt Ctrl) patients at different time points after ASCT (t0: pre-treatment; t1: first post ALI + nivolumab for treated patients and first ALI for control patient; t2: second post ALI + nivolumab for treated patients and second ALI for control patient; t3: third post ALI + nivolumab for treated patients and third ALI for control patients). Data represent the mean ± 95% CI. p < 0.05 (B) Comparison of peripheral blood NK cell subsets distribution in two patients representative of the two cohort -patient receiving ALI + nivolumab (Pt Nivo); patient receiving ALI alone (control) (Pt Ctrl)- at the different steps indicated in the Figure. ns, not significant. (C) PET scan from the patient receiving ALI + nivolumab at enrollment (upper panel C) and at end of treatment (EOT) (lower panel C). All the patients shown in Figure 4 were seropositive for HCMV, but none of them experienced HCMV reactivation during all study period.