FIGURE 3.

Schematic of mechanosensitive LCR localization to stressed actin filaments. The constitutive actin binding CRP class LIM proteins bind actin filaments in the absence or presence of force. The dashed lines indicate that CRP localization is suspected to occur for stressed actin filaments but has not been fully investigated. Mechanosensitive LIM domain protein LCR constructs bind with high affinity to actin filaments under tension or compression but with low affinity to relaxed filaments (adapted from Winkelman et al., 2020)