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. Author manuscript; available in PMC: 2021 Nov 19.
Published in final edited form as: Cytoskeleton (Hoboken). 2021 Jun 10;78(6):303–311. doi: 10.1002/cm.21677

TABLE 1.

A subset of LIM domain proteins and their corresponding mechanotransduction pathways

LIM protein Localization LCR-dependent Binding partners Mechanotransduction pathway References
Zyxin FA, AJ, SF Yes α-Actinin, VASP Ena/VASP (Drees et al., 2000; Hoffman, Jensen, Chaturvedi, Yoshigi, & Beckerle, 2012; Li & Trueb, 2001; Reinhard et al., 1999; Smith et al., 2013; Uemura, Nguyen, Steele, & Yamada, 2011)
Paxillin FA, SF Yes Vinculin, FAK, Src Rho GTPases, Microtubules (Brown, Perrotta, & Turner, 1996; Deakin & Turner, 2008; Efimov et al., 2008; López-Colomé, Lee-Rivera, Benavides-Hidalgo, & López, 2017; Smith et al., 2013; Turner, Glenney Jr, & Burridge, 1990; Watanabe-Nakayama et al., 2013; Weng, Taylor, Turner, Brugge, & Seidel-Dugan, 1993)
LIMD1 AJ, FA Yes WTIP, LATS1 HIPPO (Huggins & Andrulis, 2008; Ibar et al., 2018; G. Sun & Irvine, 2013)
Ajuba AJ Yes α-Catenin, retinoic acid receptor HIPPO, Rac (Das Thakur et al., 2010; Hou et al., 2010; Ibar et al., 2018; Marie et al., 2003; Pratt et al., 2005; Razzell, Bustillo, & Zallen, 2018)
FHL2 FA Yes Integrin, actin, titin, β-catenin Wnt, cell cycle, p21 (Johannessen, Møller, Hansen, Moens, & Van Ghelue, 2006; Nakazawa, Sathe, Shivashankar, & Sheetz, 2016)
Testin FA Calcium sensing receptor Rho kinase (Magno et al., 2011; Smith, Hoffman, & Beckerle, 2014)
Prickle FA CLASPs, LL5-β, disheveled, membrane Microtubules and CLASPs, frizzled/Dischevelled, Wnt (Han Cheng et al., 2016; Lim et al., 2016; Sweede et al., 2008; Veeman, Slusarski, Kaykas, Louie, & Moon, 2003)
Pdlim5 FA α-Actinin, protein kinase C, protein kinase D, ID2 TGF-beta (Cheng et al., 2010; Cheng et al., 2016; Kuo, 2013)
Pdlim7 FA YAP (Elbediwy et al., 2016; Kuo, 2013)
TRP6 AJ Vinculin, LATS1/2 (Dutta et al., 2018)