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. 2021 Nov 5;12:731609. doi: 10.3389/fphar.2021.731609

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Copyright © 2021 Wang, Ma, Zhang, Li, Hong, Jiang, Duan and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of GPR30 activation on cardiac function four weeks after TAC surgery in aged female mice. Mouse underwent TAC surgery three weeks after tail vein injection of GPR30 adeno-associated virus, and M-mode echocardiography was performed four weeks thereafter. (A) Representative M-mode images by echocardiography. (B) LVEF. (C) LVFS. (D) IVSd. (E) LVPWd. (F) HW/BW ratio. The results were expressed as mean ± S.E.M, n = 3–6, *p < 0.05 compared with the AG group. #p < 0.05 compared with the AG/TAC group.