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. Author manuscript; available in PMC: 2021 Nov 19.
Published in final edited form as: Nat Cell Biol. 2021 May 6;23(5):476–484. doi: 10.1038/s41556-021-00670-5

Extended Data Fig. 3 ∣. LCs and DETCs remain embedded in the basal layer of the ear epidermis upon changes in epithelial basal cell density.

Extended Data Fig. 3 ∣

(a-c) 3D reconstruction with Imaris surface rendering shows that LCs (red), DETCs (green), and epithelial cells (blue) are complicatedly intermixed in the epidermis. a, X-y and x-z views show that LCs and DETCs embed in the basal layer of the epidermis in HrasG12V mice (representative of 2 mice) 6 weeks after 1 dose of 2 mgs tamoxifen similar to (b) WT LCs and DETCs in homeostasis (representative of 3 mice) and (c) Cdkn1b;rtTA mice 3 days after induction with 1 mg/ml doxycycline (representative of 2 mice). All images: Scale bar, 10 μm.