Table 1.
Patient characteristics at the time of histological diagnosis of non-alcoholic fatty acid liver disease (NAFLD)
| Demographic data | |
| Numbers of patients | 477 |
| Gender, male/female, n | 282/195 |
| Age, year* | 53 (20–87) |
| Body mass index, kg/m2* | 26.3 (16.6–42.4) |
| Waist circumference, cm* | 91.3 (68.2–132.1) |
| Smoking, absence/presence, n | 385 /92 |
| Previous or current events | |
| Cardiovascular diseases, absence/presence/unknown, n | 444/30/3 |
| Malignancies, except for liver cancer, absence/presence/unknown, n | 426/47/4 |
| Liver-related events, absence/presence/unknown, n | 432/42/3 |
| Liver cancer, absence/presence/unknown, n | 446/30/1 |
| Ascites, absence/presence/unknown, n | 472/2/3 |
| Hepatic encephalopathy, absence/presence/unknown, n | 474/0/3 |
| Jaundice, absence/presence/unknown, n | 471/3/3 |
| Esophago-gastric varices, absence/presence/unknown, n | 463/11/3 |
| Comorbid diseases | |
| Type 2 diabetes mellitus, absence/presence, n | 321/156 |
| Hypertension, absence/presence, n | 256/221 |
| Dyslipidemia, absence/presence, n | 125/352 |
| Hyperuricemia, absence/presence, n | 420/57 |
| Chronic kidney disease, absence/presence, n | 445/32 |
| Histological findings | |
| Steatosis, 5–33%/ > 33–66%/ > 66%, n | 174/175/126 |
| Lobular inflammation | |
| No foci/< 2 foci/2–4 foci/> 4 foci per 200 × field, n | 28/263/167/17 |
| Ballooning, none/few cells/many cells, n | 42/298/135 |
| Fibrosis stage, 0/1/2/3/4, n | 55/189/77/121/35 |
| NAFLD activity score, ≤ 2/3/4/ ≥ 5, n | 38/197/242 |
| Genetic factors | |
| PNPLA3 rs738409 (CC/CG/GG/Not determined) | 57/137/135/148 |
| TM6SF2 rs58542926 (CC/CT/TT/Not determined) | 248/74/7/148 |
| ALDH2 rs671 (GG/GA/AA/Not determined) | 158/142/29/148 |
| HSD17B13 rs6834314 (AA/AG/GG/Not determined) | 162/132/25/158 |
| Laaboratory dataa | |
| Serum aspartate aminotransferase (AST), U/L | 44 (3–378) |
| Serum alanine aminotransferase (ALT), U/L | 69 (13–783) |
| Gamma-glutamyl transpeptidase, U/L | 71 (11–1,135) |
| Platelet count, × 103/mm3 | 212 (40–471) |
| Albumin | 4.1 (2.8–6.9) |
| Serum ferritin, μg/L | 227 (< 10–2.067) |
| High sensitive C-reactive protein, mg/dL | 0.097 (0.004–2.240) |
| FIB-4 index | 1.36 (0.19–14.8) |
Data represent number of patients, except those denoted by a, which represent the median (range) values
Cardiovascular diseases included coronary artery disease, heart valve disease, arrhythmia, heart failure, hypertension, orthostatic hypotension, shock, endocarditis, diseases of the aorta and its branches, disorders of the peripheral vascular system, and stroke