Table 2.

Diagnostic performance of Fibrosis-4 (FIB-4) index for the detection of liver fibrosis

Overall (n = 477)	AUROC	(95%CI)	Fib-4 cut off	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
Fibrosis stage 1–4 (n = 422) versus Fibrosis stage 0 (n = 55)	0.75	(0.69–0.81)	1.30	56.4	78.2	95.2	18.9
			2.67	20.9	98.2	98.9	13.9
Fibrosis stage 2–4 (n = 233) versus Fibrosis stage 0–1 (n = 244)	0.84	(0.80–0.87)	1.30	79.8	73.8	74.4	79.3
			2.67	36.1	98.0	94.4	61.6
Fibrosis stage 3–4 (n = 156) versus Fibrosis stage 0–2 (n = 321)	0.85	(0.81–0.88)	1.30	88.5	65.1	55.2	92.1
			2.67	46.2	94.7	80.9	78.4
Fibrosis stage 4 (n = 35) versus Fibrosis stage 0–3 (n = 442)	0.90	(0.87–0.94)	1.30	100	51.4	14.0	100
			2.67	82.9	86.4	32.6	98.5

AUROC, area under the receiver-operating characteristic curve; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value