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. Author manuscript; available in PMC: 2022 Apr 26.
Published in final edited form as: Annu Rev Immunol. 2021 Feb 12;39:537–556. doi: 10.1146/annurev-immunol-101819-092536

Figure 1: IL-17 in health and disease overview.

Figure 1:

IL-17 production and signaling is multifactorially regulated by interplay between genetics, environment and resulting microbiota populations at barrier surfaces, leading to homeostatic maintenance in healthy individuals. Injury or infection increase the IL17 effector functions that drive antimicrobial effector response and promote repair of the tissue. If the IL-17 response is inappropriately amplified due to altered input from genetic and environment factors or due to chronic stimulation that occurs during autoimmunity, persistent infection or cancer, then the antimicrobial and repair functions convert towards pathologic inflammation and tissue remodeling that promote fibrosis, tumorigenesis or autoimmune disease. Figure adapted from image created with Biorender.com.