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Influence of nabumetone on mRNA expression of CYPs (A) and transcription factors (B) in liver of SPF and GF mice in first three hours after one dose application (1; 2 and 3 hours). Data are expressed as percentage of the SPF/GF control group (100 %) without nabumetone treatment. The mRNA data represent the mean ± SD from 9 individual animals. Values significantly increased or decreased (*P<0.05; **P<0.01; ***P<0.001) in comparison with the control are labeled. NABU – nabumetone.
