Figure 3.

Anatomical localization of key brain regions is strategically placed around CSF reservoirs. The hypothalamus is located along the third ventricle and base of the brain above the basal cisterns, a prime position for CSF signaling. It contains the suprachiasmatic nucleus (red), arcuate nucleus (orange), paraventricular nucleus (yellow), ventromedial hypothalamus (green), and the supraoptic nucleus (navy), which is a hub of peptidergic signaling that controls basic biological functions such as circadian timing, reproduction, feeding, hydration, and more. The nucleus basalis of Meynert (blue), dorsal raphe nucleus (purple), and locus coeruleus (gray) are also primed for brain-wide CSF-mediated cholinergic, serotonergic, and noradrenaline signaling.