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. 2021 Nov 19;24(12):103478. doi: 10.1016/j.isci.2021.103478

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© 2021 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

BAL obtained from non-COVID-19 and COVID-19 individuals denote a high concentration of inflammatory mediators released by opening Panx-1 channels

BAL was obtained from individuals with COPD, n = 30 for the non-COVID-19 conditions (COVID-19(−)) or with mild/acute COVID-19 (COVID-19 (+)), n = 30. BAL was inactivated using temperature (65°C for 30 min), and ELISA for (A) ATP, (B) PGE₂, and (C) IL1β was performed according to the manufactured instructions. BAL from COVID-19 individuals had higher amounts of these mediators as compared with non-COVID-19 individuals. ATP, p = 0.0064 compared with COVID-19(−); PGE₂, p = 0.0014 compared with COVID-19(−) and IL-1β, p = 0.0031 compared with COVID-19(−), n = 30.