Table 3.
circRNAs with diagnostic or prognostic values in PCa.
| Description | Area under Curve (AOC) | Sensitivity | Specificity | Kaplan–Meier analysis | Univariate Cox regression | Multivariate cox regression | Other correlation tests | Ref. (s) |
|---|---|---|---|---|---|---|---|---|
| 5-circRNA signature | – | – | – | Higher expression of cognate genes for hsa_circ_0006410, hsa_circ_AKAP7 and hsa_circ_0005848 positively correlated with better OS in PCa patients. | – | – | – | (29) |
| 5-circRNA signature | 0.827 | – | – | PCa patients at the high-risk group with higher expression of hsa_circ_0000437, hsa_circ_0000280, and circ_5017 had lower survival compared to the low-risk group. | Autophagy-related prognostic risk score was correlated with survival in PCa patients. | – | (97) | |
| circABCC4 expression in PCa patients | – | – | – | Higher circABCC4 levels positively correlated with survival in PCa patients | – | – | The Chi-square test showed association between circABCC4 expression and advanced clinicopathological features including higher tumor stage and metastasis | (53) |
| circMBOAT2 expression in a cohort including 50 PCa patients and matched NATs (high: 31 samples, low: 31 samples) | – | – | – | High circMBOAT2 expression correlated with shorter DFS in two cohorts of PCa patients | Increased expression significantly associated with poorer prognosis in PCa patients. | The χ 2 test demonstrated positive correlation between circMBOAT2 expression and advanced clinicopathological features including higher pathological T stage and Gleason score in PCa patients | (30) | |
| circFOXO3 via SLC25A15 axis | – | – | – | High SLC25A15 expression correlated with shorter OS in PCa patients | – | – | - High SLC25A15 circFOXO3 expression was significantly associated with advanced Gleason score in PCa patients - Increased expression of SLC25A15 correlated with poorer prognosis | (31) |
| circ_0057558 | – | – | – | circ_0057558 knockdown in increased OS nude mice | – | – | – | (46) |
| circHIPK3 | – | – | – | – | – | – | High circHIPK3 expression predicted poorer prognosis for PCa patients | (56) |
| – | – | – | – | – | – | miR-338-3p high expression levels as target of circHIPK3 correlated with histological grade, lymph node metastasis and distant metastasis. | (57) | |
| circPDHX | 0.64 | 80.0% | 58.7% | PCa patients with elevated circPDHX expression levels had poorer survival relative to patients with low levels | circPDHX high expression level along with advanced Gleason score act as independent prognostic factors for PCa patients predicting poorer survival. | High circPDHX expression significantly correlated with high pathological T stage and Gleason score in PCa patients | (98) | |
| circ-TRPS1 | – | – | – | – | – | – | The Pearson’s correlation test showed an association between increased circ-TRPS1 expression and advanced clinicopathological features including higher T stage, lymph and distant metastasis. High circ-TRPS1 expression correlated with poorer prognosis in PCa patients | (63) |
| circ-0016068 | – | – | – | PCa patients with elevated circ-0016068 expression exhibited decreased survival compared to those with lower levels. | – | – | The Fisher’s exact test showed correlation between high circ-0016068 expression and advanced clinicopathological features including higher pathological T stage, Gleason score, and lymph node metastasis. | (65) |
| circ_0062020 | – | – | – | – | – | – | The Chi-square test showed correlation between high circ_0062020 expression and advanced clinicopathological features including higher tumor size, TNM stage, Gleason score and lymph node metastasis in PCa patients. | (99) |
| hsa_circ_0000735 | – | – | – | Patients with high hsa_circ_0000735 expression showed shorter OS compared to those with low levels. | – | – | – | (67) |
| circFMN2 | – | – | – | – | – | – | High circFMN2 expression showed association with high pathological T stage, lymph node and distant metastasis. circFMN2 was detected in exosomes extracted from serum of PCa patients. | (32) |
| circ-ITCH | – | – | – | Low circ-ITCH level significantly correlated with poorer OS in PCa patients. | – | – | Low circ-ITCH expression correlated with advanced clinicopathological characteristics including higher tumor stage, Gleason score and high PSA levels. | (77) |
| 0.812 | 88.3% | 61.7% | PCa patients with high circ-ITCH expression had better survival including longer DFS and also improved OS. | High circ-ITCH levels were associated with longer DFS in PCa patients. | circ-ITCH level acts as an independent prognostic factor. | Low circ-ITCH levels correlated with unfavorable clinicopathological features including advanced pathological T stage and lymph node metastasis. | (78) | |
| hsa_circ_0001633, hsa_circ_0001206, and hsa_circ_0009061 | 0.809, 0.774, and 0.711, respectively | – | – | – | – | – | hsa_circ_0001206 and hsa_circ_0009061 expression levels correlated with high Gleason score and tumor stage in PCa patients. | (80) |
| circ_LARP4 | – | – | – | PCa patients with decreased circ_LARP4 expression levels exhibited poorer OS and worse prognosis compared to those with high levels. | – | – | – | (83) |
| circ-MTO1 | – | – | – | PCa patients with high circ-MTO1 levels showed longer OS and DFS. | High circ-MTO1 levels predicted favorable OS and prognosis. | circ-MTO1 expression act as an independent predictive factor predicting better prognosis. | High circ-MTO1 expression levels were significantly associated with better clinicopathological features including lower pathological T stage and N grade in PCa patients. | (84) |
| circPSMC3 | – | – | – | PCa patients with low circPSMC3 expression levels exhibited worse prognosis compared to those with high levels. | – | – | – | (86) |
| circSLC8A1 | – | – | – | – | – | – | Patients with low circSLC8A1 expression exhibited shorter survival compared to those with high levels. | (87) |
| circRNA signature | 0.799 | – | – | Up-regulated circRNAs in the signature were correlated with less survival and down-regulated circRNAs were significantly associated with less recurrence. | – | – | – | (89) |