Table 4.

Comparison of current analysis with original study results and outcomes

Score	Reference, country	Included predictors	Original outcome(s)	AUC (95% confidence interval)b
				Original publication	Current analysis
CALL	Ji et al., China [10]	Comorbidity, age, LDH, lymphocyte count	Respiratory rate ≥ 30 bpm, SpO2 ≤ 93%, PaO2/FiO2 ≤ 300 mmHg, mechanical ventilation, worsening of lung CT findingsa	0.91 (0.86–0.94)	0.61 (0.55–0.68)
	Grifoni et al., Italy [14]			External validation
				0.62 (0.53–0.69)
CHOSEN	Levine et al., United States [11]	Age, FiO2, albumin	Hypoxia, ICU admission, death (within 14 days)	0.89 (0.87–0.91)	0.65 (0.59–0.71)
				Validation cohort
				0.87 (0.81–0.93)
HA2T2	Manocha et al., United States [12]	Supplemental oxygen, age, troponin	All-cause in-hospital mortality	0.83 (0.79–0.88)	0.78 (0.70–0.85)
				Validation cohort
				0.78 (0.72–0.84)
ANDC	Weng et al., China [13]	Age, NLR, d-dimer, CRP	All-cause in-hospital mortality	0.92 (0.84–0.97)	0.66 (0.56–0.77)
				Validation cohort
				0.98 (0.95–1.00)

AUC area under the curve, bpm breaths per minute, CRP C-reactive protein, CT computer tomography, FiO₂ fraction of inspired oxygen, ICU intensive care unit, LDH lactate dehydrogenase, NLR neutrophil-to-lymphocyte ratio, PaO₂ arterial partial pressure of oxygen, SpO₂ peripheral oxygen saturation

^aCT findings not included in our results, data not available

^bAll results calculated for original outcomes